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KMID : 0380619870190040311
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Korean Journal of Food Science and Technology
1987 Volume.19 No. 4 p.311 ~ p.316
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The Role of Active Oxygen on DNA Damage by Linoleic Acid Peroxidation Products
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이용우/Lee, Yong Woo
김인수/박영호/강진훈/김선봉/Kim, In Soo/Park, Yeung Ho/Kang, Jin Hoon/Kim, Seon Bong
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Abstract
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The present paper was carried out to investigate the effects of active oxygen radicals on the DNA damage by linoleic acid peroxidation by using active oxygen scavengers in a linoleic acid-DNA system. DNA was greatly damaged by linoleic acid peroxidation, and the DNA damage was inhibited by the addition of active oxygen scavengers. Among active oxygen scavengers tested, α-tocopherol and superoxide dismutase greatly inhibited the DNA damage, but catalase and iris (hydroxymethyl) aminomethane didn´t show such effects. Accordingly, singlet oxygen and superoxide anion greatly affected to the DNA damage occurring during linoleic acid peroxidation, and hydrogen peroxide was shown to participate in DNA damage in the early stage of peroxidation. And, the DNA damage by active oxygen. radicals was mainly induced in the early stage of linoleic acid peroxidation.
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KEYWORD
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